In this paper, the structure of a southeastern Spanish population was studied for the first time with respect to its inbreeding patterns and its relationship with demographic and geographic factors. Data on consanguineous marriages from 1900 to 1969 were taken from ecclesiastic dispensations. Our results confirm that the patterns and trends of inbreeding in the study area are consistent with those previously observed in most non-Cantabrian Spanish populations. The rate of consanguineous marriages was apparently stable between 1900 and 1935 and (...) then sharply decreased since 1940, which coincides with industrialization in Spain. A marked departure from Hardy-Weinberg expectations in the ratio of first cousin to second cousin marriages in the study population was observed. The high levels of endogamy and its significant steadiness throughout the twentieth century is noteworthy. Accordingly, our results show that exogamous marriages were not only poorly represented but also that this reduced mobility suggests that the choice of a mate was preferentially local. We found higher mobility in M22 with respect to M33 cousin mating. The relationships between population size and consanguinity rates and inbreeding fit power-law distributions. A significant positive correlation was observed between inbreeding and elevation. Many Spanish populations have experienced a prolonged and considerable isolation across generations, which has led to high proportions of historical and local endogamy that is associated, in general, with high \ values. Thus, assessing genomic inbreeding using runs of homozygosity in current Spanish populations could be an additional pertinent strategy for obtaining a more refined perspective regarding the population history inferred from the extent and frequency of ROH regions. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

© 2016 Regents of the University of California.The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,062 new measurements from 721 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. All the particle properties and search limits are listed in Summary Tables. We also give numerous (...) tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 117 reviews are many that are new or heavily revised, including those on Pentaquarks and Inflation. The complete Review is published online in a journal and on the website of the Particle Data Group. The printed PDG Book contains the Summary Tables and all review articles but no longer includes the detailed tables from the Particle Listings. A Booklet with the Summary Tables and abbreviated versions of some of the review articles is also available. (shrink)

This paper aims to improve knowledge about the main factors influencing firm environmental commitment, by examining empirically the relationship between public support for R&D for small and medium enterprises (SMEs) and their investment in environmental protection. The empirical analysis was developed using a sample of 1594 Spanish firms, and a binary logistic regression to evaluate the existence of dependency relationships between the analyzed variables. The results show that those companies receiving direct funding from local public entities and those collaborating with (...) research centers and universities, invest more in environmental actions to protect the natural ecosystem. The paper contributes to the academic literature by analyzing the main factors that influence the SMEs environmental commitment. Moreover, showing practitioners and policy makers the effectiveness of different types of financial support depending on the origin of the funds and the form of action taken; showing managers the advantages of collaborating with public administrations, as well as with other research organizations, to obtain better ECSR results. (shrink)

"By combining recent advances in the physical sciences with some of the novel ideas, techniques, and data of modern biology, this book attempts to achieve a new and different kind of evolutionary synthesis. I found it to be challenging, fascinating, infuriating, and provocative, but certainly not dull."--James H, Brown, University of New Mexico "This book is unquestionably mandatory reading not only for every living biologist but for generations of biologists to come."--Jack P. Hailman, Animal Behaviour , review of the first (...) edition "An important contribution to modern evolutionary thinking. It fortifies the place of Evolutionary Theory among the other well-established natural laws."--R.Gessink, TAXON. (shrink)

I would refer to the introductory paragraphs of J. Diggle's ‘Notes on Ovid's Tristia, Books I-II’ , 401–19). His list of modern editions does not include F. Della Corte, I Tristia , which I too have not seen. For Book IV we have an edition by T. J. de Jonge.

People who trust modern indexes will suppose that the name of Sex. Clodius, the disreputable henchman of Publius, comes twice in the Ad Atticum letters, 14. 13. 6 and 14. 13 A. 2. The manuscripts give it as follows.

R. Renehan's ingenious solutions to the problems of Symphosius 42. 1 and Anth. Lat. 207 in this journal, 471 f.) are much to be welcomed. On the other hand, I do not think that his defence of the manuscript reading in Anth. Lat. 24. 3 marcent post rorem violae, rosa perdit odorem holds water. Taking rorem as = rorem marinum he explains that ‘the poet is not presenting us with a piece of botanical information about the relative seasons of the (...) violet and rosemary; he means rather that all flowers wither and fade’. Actually, however, the poet on this showing does present information; and whether the information is botanically correct or not, that is an odd way to make his point. Stranger still is his choice of rosemary out of all the fading flowers of field and garden. It was bound to be I misunderstood. As Renehan indicates, ros = ros marinus is supported only by Virg. Georg. 2. 212–13, where the identity has been doubted, and Plin. HN 24. 100, where ex rore supra dicto refers back to ros marinum in 99. Renehan may well be the first reader not to take rorem as dew. And an evergeen shrub makes a singularly unfortunate illustration of floral decay, even though the shrub does produce a flower. Pliny classes it with herbs. (shrink)

Offers a comprehensive nonmathematical treatment regarding the design and analysis of experiments, focusing on basic concepts rather than calculation of technical details. Much of the discussion is in terms of examples drawn from numerous fields of applications. Subjects include the justification and practical difficulties of randomization, various factors occurring in factorial experiments, selecting the size of an experiments, different purposes for which observations may be made and much more.

The text of Quintus Curtius benefited greatly from Conrad Müller's edition of 1954 . In particular, his thorough investigation of Curtius' rhythms enabled him to settle many hitherto doubtful points. Problems remain, unsolved or undetected. In Curtius, as in other prose texts, scribal omissions are a prolific source of corruption, sometimes productive of interpolation. Most of the following notes postulate corruptions of this type.

The text of Quintus Curtius benefited greatly from Conrad Müller's edition of 1954. In particular, his thorough investigation of Curtius' rhythms enabled him to settle many hitherto doubtful points. Problems remain, unsolved or undetected. In Curtius, as in other prose texts, scribal omissions are a prolific source of corruption, sometimes productive of interpolation. Most of the following notes postulate corruptions of this type.

10. 2. lugentem timentemque custodire solemus, ne solitudine male utatur. Reynolds does not mention Haupt's conjecture amentemque, which is certainly on the right lines. Bereaved persons may need watching because in the violence of their grief they may do themselves an injury , and the same applies to madmen or to anyone suspected of suicidal inclinations custodio). It does not apply to persons afraid; they may sometimes be glad of company, but do not require surveillance. My only doubt is whether (...) amentem, seldom used of actual insanity, is the right word. Perhaps dementem or furentem, which makes a better match with the participle lugentem. (shrink)

Seneca ‘Rhetor’ was last critically edited by H. J. Müller in 1887; the editions of H. Bornecque and W. A. Edward lack an apparatus criticus, though the latter's notes give some attention to textual points. Whoever next addresses himself to the task can take heart from Eduard Norden : ‘der Text ist schwer korrupt, für Konjekturalkritik noch viel zu tun.’ It may be added that he will do a service by jettisoning a large proportion of what Konjekturalkritik has already produced-too (...) much of this nature in Müller's text and apparatus, to say nothing of later contributions, is merely depressing. (shrink)

Seneca ‘Rhetor’ was last critically edited by H. J. Müller in 1887; the editions of H. Bornecque and W. A. Edward lack an apparatus criticus, though the latter's notes give some attention to textual points. Whoever next addresses himself to the task can take heart from Eduard Norden : ‘der Text ist schwer korrupt, für Konjekturalkritik noch viel zu tun.’ It may be added that he will do a service by jettisoning a large proportion of what Konjekturalkritik has already produced-too (...) much of this nature in Müller's text and apparatus, to say nothing of later contributions, is merely depressing. (shrink)

10. 2. lugentem timentemque custodire solemus, ne solitudine male utatur. Reynolds does not mention Haupt's conjecture amentemque, which is certainly on the right lines. Bereaved persons may need watching because in the violence of their grief they may do themselves an injury, and the same applies to madmen or to anyone suspected of suicidal inclinations custodio). It does not apply to persons afraid; they may sometimes be glad of company, but do not require surveillance. My only doubt is whether amentem, (...) seldom used of actual insanity, is the right word. Perhaps dementem or furentem, which makes a better match with the participle lugentem. (shrink)

Few authors, I should suppose, get less expert treatment in this lexicon than Cicero, so far at least as his letters are concerned. That is largely because the editors chose to trust Tyrrell and Purser, to whom Cicero's Greek was no less full of pitfalls than his Latin. The following notes may be of help in the preparation of a tenth edition.

Cicero's use of the term is hardly a joke, and has to do with medicine, not logic. He says that his predecessor as governor of Cilicia, App. Claudius Pulcher, is like a doctor whose patient has been transferred to another practitioner, and who takes offence when the new man alters the treatment.

Few authors, I should suppose, get less expert treatment in this lexicon than Cicero, so far at least as his letters are concerned. That is largely because the editors chose to trust Tyrrell and Purser, to whom Cicero's Greek was no less full of pitfalls than his Latin. The following notes may be of help in the preparation of a tenth edition.

Cicero's use of the term is hardly a joke, and has to do with medicine, not logic. He says that his predecessor as governor of Cilicia, App. Claudius Pulcher, is like a doctor whose patient has been transferred to another practitioner, and who takes offence when the new man alters the treatment.

Few authors, I should suppose, get less expert treatment in this lexicon than Cicero, so far at least as his letters are concerned. That is largely because the editors chose to trust Tyrrell and Purser, to whom Cicero's Greek was no less full of pitfalls than his Latin. The following notes may be of help in the preparation of a tenth edition.

Critics, once so busy with Manilius, have left him alone since Housman's edition was completed a quarter of a century ago. Perhaps I shall seem rash to break the silence by challenging a few of his verdicts. I do so in no spirit of iconoclasm, but rather believing that Housman wrote for readers who will occasionally call him wrong—at their peril, and on their knees.

‘He was of Rutulian blood, born of a Saguntine mother; but he had Greek blood too, and by his two parents he combined the seed of Italy with that of Dulichium’. So Duff, and Ruperti's ‘Murrus matre Graia et patre Romano progenitus’ is not the whole story. To Silius Saguntine = Greek because, as Duff says, ‘men of Zacynthos had taken part in founding Saguntum’. prole = ‘with his children’—van Veen's Itala may well be right.

‘He was of Rutulian blood, born of a Saguntine mother; but he had Greek blood too, and by his two parents he combined the seed of Italy with that of Dulichium’. So Duff, and Ruperti's ‘Murrus matre Graia et patre Romano progenitus’ is not the whole story. To Silius Saguntine = Greek because, as Duff says, ‘men of Zacynthos had taken part in founding Saguntum’. prole = ‘with his children’—van Veen's Itala may well be right.